It occurs when the sides of the facial skin fuse in a developing baby abnormally.

In the March 15 problem of the journal Advancement, NIDCR grantees and colleagues record the discovery of two genes that will tend to be involved in individual clefting. The genes are: Bmp4, a member of the so-known as bone morphogenetic protein family that regulate intercellular communication during fetal advancement, and Bmpr1a, the receptor for the Bmp4 protein. The researchers also report that Bmp signaling generally has distinct features in forming the lip and secondary palate. In the lip, the Bmp signaling appears to become a survival signal to impact the timing of programmed cell death. In the secondary palate, Bmp signaling regulates the proliferative capacity of cells that are destined to create the roofing of the mouth. To read more about this scholarly study, click here.. Continue reading