Proteome-wide measurements from 8 independent experiments robustly showed that only plasmacytoid dendritic cells from patients with early systemic sclerosis secreted a unique pattern of peaks which were identified as CXCL4, CTAP-III, S100A8/9, and lysozyme . Confirmatory assessments showed markedly increased levels of CXCL4 in patients with systemic sclerosis . Increased levels of CXCL4 messenger RNA were observed just in purified plasmacytoid dendritic cells, and elevated CXCL4 proteins expression was seen in circulating plasmacytoid dendritic cells and in plasmacytoid dendritic cells in skin from patients with systemic sclerosis .The statewide plan's goal is to bring the cutting-edge improvements in prostate malignancy care and research from the world-leading hospitals to every guy, his caregiver, and health care providers in Massachusetts. The advanced approaches to screening, treatment and medical diagnosis are anticipated to save lives, improve standard of living, and reduce healthcare costs. The marketing campaign will be centered on men at risky of lethal prostate tumor, including people with African heritage, genealogy, and increasing age group.