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Most of them have been already reflected in the worldwide surveys carried out by different businesses including world health firm. Women who feel that they cannot raise the youngster in socially well balanced environment sought to abortion, financially poor condition, career oriented goals, unwanted or unplanned pregnancy, failure of contraceptive actions, migration from one country to another, political volatile circumstance such as battle, terrorism, riots etc.Chemotherapy, proton-pump inhibitors, and H2 blockers may disrupt the bowel flora and allow for C. Difficile colonization. Antibodies against toxin B may permit colonization by C. Difficile but prevent an infection. Difficile colonization. This total result is supported by a study of C. Difficile infection showing that toxin B is essential, and toxin A is usually less important, for virulence15; other studies have shown that C. Difficile strains that are harmful for toxin A but positive for toxin B can cause disease.26,27 Furthermore, low levels of serum antibodies against the receptor-binding epitope domain of toxin B have already been significantly connected with recurrent disease.28 Hence, antibodies against toxin B may possess protective effects and could be a potential focus on for vaccine development.