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In addition, the fear of weight gain in patients not want to start insulin treatment and reduce patient compliance lead.References:1 Ackermann RW, Hansen JB, Nauck M. Basal-bolus therapy with insulin detemir / insulin aspart improves glycemic control and reduced hypoglycemia: data from the German cohort of the study PREDICTIVETM. European Association of the Study of Diabetes Congress 2006th Poster number 978th Tiengo A Waldhuusel W et al. Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes. Diabetes, Obesity and Metabolism. 2005 Jan, 7 :56-64. Hermansen K, Fontaine P, Kukolja K et al. Insulin analogues versus traditional human insulin in basal-bolus therapy for patients with type 1 diabetes. Diabetologia , 47:622-629. PREDICTIVETM : to assess a global, prospective, observational study of insulin detemir treatment in type 1 and type – 2 diabetes: German cohort data. American Diabetes Association: 66th Annual Scientific Sessions c, Washington, Poster 511 – P. Heise T, Klein O, Lynge L et al. Insulin detemir and insulin glargine similar time-action profiles in patients with type 2 diabetes. European Association for the Study of Diabetes Congress 2006th Oral presentation 146th The DCCT Research Group. Weight gain with intensive therapy in the Diabetes Control and Complications Trial connected. Diabetes Care 1998, 11:567-573. Dr Nishan Wijenaike. Insulin Treatment and Weight Gain. The West Suffolk Diabetes Service, November 2004. Levemir Summary of Product Characteristics.