Charles Lutcher.

Information concerning self-reported race, age, baseline intensity of hemophilia, results of previous screening for inhibitors, and additional affected family was obtained from medical information and interviews with patients by the nurses involved with enrollment. To take into account nonindependence of subjects because of family relationships, all individuals with affected relatives had been asked whether any relative was being treated at the participating centers and thus might be enrolled in this study. Inhibitor Determination and Surveillance of Baseline Intensity of Hemophilia Data on inhibitors were obtained from reviews of the medical charts by the nurses.

In the per-protocol analysis, 28.5 percent of participants in the ischemic-preconditioning group had major adverse cardiac and cerebral events within 12 months, in comparison with 27.2 percent in the control group . There is no evidence that the effect of remote ischemic preconditioning in comparison with the result of sham preconditioning differed significantly within the subgroups for just about any of the prespecified end factors . Post hoc subgroup analyses showed no proof that the result of remote ischemic preconditioning on the primary composite end stage differed significantly based on the type of anesthetic used during medical procedures or the interval between the start of remote control ischemic preconditioning and initiation of cardiac bypass .In the per-protocol analysis, 28.5 percent of participants in the ischemic-preconditioning group had major adverse cardiac and cerebral events within 12 months, in comparison with 27.2 percent in the control group . There is no evidence that the effect of remote ischemic preconditioning in comparison with the result of sham preconditioning differed significantly within the subgroups for just about any of the prespecified end factors . Post hoc subgroup analyses showed no proof that the result of remote ischemic preconditioning on the primary composite end stage differed significantly based on the type of anesthetic used during medical procedures or the interval between the start of remote control ischemic preconditioning and initiation of cardiac bypass .