Nicholas C read . Turner, M.D., Ph.D., Jungsil Ro, M.D.D., Ph.D., Sherene Loi, M.D., Ph.D., Sunil Verma, M.D., Hiroji Iwata, M.D., Nadia Harbeck, M.D., Sibylle Loibl, M.D., Cynthia Huang Bartlett, M.D., Ke Zhang, Ph.D., Carla Giorgetti, Ph.D., Sophia Randolph, M.D., Ph.D., Maria Koehler, M.D., Ph.D., and Massimo Cristofanilli, M.D.1 Despite advances in endocrine therapy, a lot of women possess a relapse during or after completing adjuvant therapy. The care of these women remains a significant clinical challenge. Single-agent treatment with an aromatase inhibitor or tamoxifen shows limited clinical advantage.2,3 The selective estrogen-receptor degrader fulvestrant has modest activity in this population of sufferers,4,5 and the advancement of effective therapies that can reverse resistance to endocrine therapy is of clinical importance.
8,000 scientific papers link refined white sugar to chronic disease One of the worst things you can do to your body is definitely feed it sugar – – not necessarily natural sugar just like the kind within fruit, but refined sugar. A team of researchers from the University of California in SAN FRANCISCO BAY AREA recently pored through a lot more than 8,000 scientific papers on how sugar affects your body and deducted that it not merely makes people unwanted fat but also makes them sick. The project, which includes been dubbed SugarScience, exposes glucose as a major culprit in the forming of metabolic disease, that may result in conditions like heart type and disease 2 diabetes. Lead author Laura Schmidt, a UCSF School of Medicine professor, says her team’s findings are comprehensible – – glucose is highly toxic to the body and vital organs, including the liver.