This finding suggested that the severe phenotype is the effect of a truncating mutation in the CHUK gene that results in the complete loss of CHUK protein expression. Expression Data and Pathway Analysis To investigate the consequences of the increased loss of CHUK in the affected fetuses, we analyzed the genomewide expression arrays with the WebGestalt program additional. Table 2 in the Supplementary Appendix shows differentially expressed genes in some of the enriched Gene Ontology categories. One particular gene encodes matrix metallopeptidase 14 , a protein essential for skeletal advancement12 and the forming of arteries.13 We assayed MMP-14 protein in fetal fibroblasts by means of Western blotting and observed that MMP-14 was expressed at the proteins level in the affected fetuses however, not in age-matched control fetuses .In December 2009 The 24-month clinical readout from the analysis was completed and announced. This NDA submission contains the 24-month low dosage data from the FAME Research. Alimera plans to follow this NDA submission with sign up filings in certain European countries and Canada in the near future.
Administration cites Hobby Lobby ruling in response to challenge by religious nonprofits The Obama administration cites the Supreme Court's opinion Wednesday to buttress its claim it has offered spiritual nonprofits an acceptable compromise to medical rules's contraceptive insurance coverage mandate. Meanwhile, House Democrats craft legislation that would bar for-profit businesses from denying birth control coverage with their employees. The Wall Street Journal: Administration Points To Hobby Lobby Ruling In Wheaton University Case In the most recent battle over the Inexpensive Care Act, the Obama administration Wednesday cited the Supreme Court's Hobby Lobby ruling to buttress the state it has offered spiritual nonprofits a satisfactory compromise to opt out of contraceptive protection in employee health plans.