Today announced outcomes of preclinical research on ponatinib.

ARIAD scientists are presenting the data this morning at the American Association for Malignancy Research Annual Getting together with in Orlando, Florida. The new data on ponatinib show potent activity against a wide selection of tumor cells activated by all FGFRs, in vitro and in vivo. In a panel of 14 cell lines representing multiple different tumor types including endometrial, bladder, gastric, breast, lung and colon cancer, ponatinib and selectively inhibited FGFR-mediated signaling and cell growth potently. Four additional tyrosine kinase inhibitors with FGFR inhibitory activity that are in scientific development were substantially less active, and none potently blocked all four FGF receptors.You are not likely to take any medications without consulting your doctor while taking Isotretinoin. Isotretinoin and Pregnancy Isotretinoin can cause significant defects in the fetus. Therefore you should inform your physician if you are pregnant. It’s also advisable to tell your doctor if you plant to be pregnant or breast-feeding. You have to check yourself for being pregnant before starting Isotretinoin and continue obtaining tested while acquiring Isotretinoin. Your doctor shall explain the details to you. If you get pregnant while acquiring Isotretinoin you should prevent taking it and call your doctor immediately. You need to adopt two reliable ways of birth control for just one month before acquiring Isotretinoin, continue while taking Isotretinoin and till after a month of stopping Isotretinoin.