Missing genes may help plague bacteria plague bacteria are so deadlyWhat is the germ that causes plague so terribly lethal, while a close relative only produces digestive disorders and is rarely fatal?or in the genes – or rather the lack of them article .The comparison of the genome of the plague bacillus, Yersinia pestis, with nearly identical DNA sequence of Yersinia pseudotuberculosis, an international team of scientists at Lawrence Livermore National Laboratory has conducted found that several hundred genes that were apparently inactivated as the plague bacterium can develop largely responsible for their virulence. – In a report published today in the online edition of the Proceedings of the National Academy of Sciences, the researchers said the massive gene loss and DNA rearrangements, than the Y. Has has developed a sobering example of how a highly virulent epidemic can suddenly emerge from a less virulent, closely related progenitor cells. .
Sequencing of Y. Pseudotuberculosis genome was part of a Bio-Foundation Initiative by the U.S. Department of Energy’s Chemical and Biological Nonproliferation Program funding, in collaboration with Elisabeth Carniel of the Institut Pasteur. Also participating in the project were researchers from the Life Sciences Division at Oak Ridge National Laboratory, Oak Ridge, Tennessee, of our time.te of Microbiology and Molecular Genetics at Michigan State University, East Lansing, Rocky Mountain Laboratories in Hamilton, The National Institute for Sante et de la Recherche Medicale at the Universite de Lille in France and Genoscope and the Centre National de la Recherche Scientifique – Unite Mixte de Recherche in Evry Cedex, France.
Duloxetine, a member of one class of drugs that that is commonly referred as serotonin and noradrenaline reuptake inhibitor is 70 countries for the 70 countries for the treatment of depression. While traditional the focus the treatment treating just emotionally symptoms of depression, we know now that the presence of physical symptoms especially pains, obscure the diagnosis and complicate the treatment of patients, said Professor Koen Demyttenaere, Department of psychiatry at the University Gasthuisberg in Belgium and and lead study investigator. 29.6 to 18.29 to at least moderate pain of duloxetine helped to by significantly reducing in both painfully and emotionally symptoms of depression, and in reducing interference out of pain related to function. .
Clinical trials GVAX cancer immunotherapies are ongoing for several kinds of cancer addition to pancreatic cancer, including prostate cancer and Leukaemia. The products will be. Tumor cell the secretion of to secrete GM-CSF, the immune colony stimulating hormone, and then irradiated safety security of the company cancer immunotherapies to be non as the patient – specific off-the-shelf pharmaceutical products designed and have demonstrated a favorable side effects in on 600 patients in clinical trials to date.